Women these days are walking along with men, and we cannot deny the fact that they are doing great in their professions. The tale of scientific progress has been largely male-dominated for decades, hiding the priceless contributions of women who have continuously pushed the limits of knowledge and creativity. These women persisted in the face of institutionalized prejudice, cultural norms, and overt discrimination, changing science and our perception of the world in the process. The remarkable accomplishments of well-known female scientists who disregarded expectations broke with tradition, and transformed their areas are honored in this article. In addition to advancing scientific knowledge, their groundbreaking discoveries and unrelenting commitment have changed the face of science and motivated generations of women to seek professions in STEM.